Discovery Programs:
Regeneration of sensory hair cells
Repair and restoration of hair bundles
Regeneration of auditory nerve fibers
Treatment of genetic defects by gene therapy and gene editing
We are developing first-in-class therapeutics to treat sensorineural hearing loss, especially age-related progressive hearing loss. Our drug discovery research focuses on repairing the tiny hair-like structures (hair bundle or stereocilia) that sense sound waves, regenerating lost hair cells, and restoring the auditory nerve fibers that connect to them. We also use advanced genetic approaches, such as gene therapy, gene editing, and transcriptional activation, to develop treatments for congenital hearing loss in children and forms that progress with age.
Drug Discovery Platforms
We have built cutting-edge drug discovery platforms using adult cochlear tissue explant, stem-cell-derived inner ear organoids, and animal models. These tools enable us to discover new biological targets, identify promising drug candidates, and validate combination therapies with the potential to restore hearing.
Hair Cell Regeneration
reprogramming
(new hair cell formation)
(new hair cell)
Cochlear Explant Culture
(new hair cell formation)
iPSC-derived Inner Ear Organoids
